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The Impact of Genetic and Environmental Risk Factors on Liver Disease Susceptibility in a Cohort of Mexican Adults

This project aims to examine the individual and combined effects over time that specific environmental and genetic risk factors have on chronically elevated aminotransferase levels in a cohort of Mexican adults, using existing clinical and questionnaire data collected from 756 cases and 677 controls in 2004-2006 and 2011-2012; to identify candidate genes, as well as other genes and single-nucleotide polymorphism associated with the development and prognosis of NAFLD and NASH among 197 cases and 677 control that were identified during 2004-2006 and followed up in 2011-2012; to explore the effect modification of specific genes and SNPs on the association between risk factors such as diet, obesity, and diabetes, and the development and prognosis of NAFLD and NASH.

Start Date: 
July 1, 2012
End Date: 
June 30, 2014